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doi: 10.1371/journal.pone.0003815 116 GrafWDMarin-GarciaJGaoHGPizzoSNaviauxRKMarkusicDet al

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Off-target activity may vary by concentration and species

(30 )

For oral administration, polymeric nanoparticles offer controlled release and high drug-loading potential, but are prone to protein corona formation in vivo , which compromises targeting capabilities

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